Researchers revealed that miR-148a promoted mouse fetal hepatoblasts (MFHs) differentiating to mature hepatocytes by directly targeting DNA methyltransferase 1 (DNMT1) [23] and induced hepatocytic differentiation to HCC by inhibiting IKKα/NUMB/NOTCH signaling [34]. The gene discussed is NUMB; the disease is hepatocellular carcinoma.