PDCD6 and cancer: To investigate the role of PDCD6 in CRC progression, we analyzed the PDCD6 mRNA transcripts of different patient samples in the GEPIA database and found that PDCD6 was highly expressed in multiple kinds of cancer, including breast invasive carcinoma (BRCA), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), colon adenocarcinoma (COAD) and rectal adenocarcinoma (READ) (Fig. 1a and Supplementary Fig.S1).