The results showed that NSCLC cells with downregulated circ-CPA4 significantly increased the proliferation ability (Fig. 9a) and viability (Fig. 9b), and inhibited cell apoptosis (Fig. 9c-e) of CD8+ T cells in the co-culturing system, while overexpression of circ-CPA4 had opposite effects on the above cell functions (Fig. 9a-e). The gene discussed is CPA4; the disease is non-small cell lung carcinoma.