GDF15 and coronary artery disorder: The predictive value of GDF-15 in ACS has been confirmed in the 2 large non-ST-segment-elevation ACS (NSTE-ACS) trials: the GUSTO-IV (Global Utilization of Strategies to Open Occluded Arteries IV) and FRISC II (Fast Revascularization during Instability in Coronary Artery Disease II) cohorts [12, 15].