A study conducted by the Splenic Marginal Zone Lymphoma Working Group (SMZL-WG), involving 593 patients from different centers, identified Hb < 95 g/L, platelets < 80 x 109/L, elevated LDH and the presence of extra-hilar lymphadenopathy as variables associated with adverse prognosis, representing another widely used prognostic score in clinical practice [15]. This evidence concerns the gene GSTM1 and lymphoma.