Stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS) is an autosomal recessive disorder caused by defects in the ADP-Ribosylhydrolase Like 2 (ADPRHL2; OMIM: 618170) gene. This evidence concerns the gene ADPRS and neurodegeneration, childhood-onset, stress-induced, with variable ataxia and seizures.