The cyan module that was linked to the number of APOE ε4 alleles is involved in GO pathways related to the immune system, which is interesting given that the immune system is known to be activated in AD (Heppner et al., 2015), and as APOE ε4 is the strongest genetic risk factor for sporadic AD (Lambert et al., 2013). This evidence concerns the gene APOE and Alzheimer disease.