The average methylation level across the CPT1B/CHKB DMR was significantly correlated with gene expression across all samples (r = 0.40, p = 8.62 × 10−5, Supplementary Fig. 5), which appeared to be primarily driven by a correlation observed in the MCI-MCI samples (r = 0.49, p = 7.27 × 10−5) and not the MCI-AD samples. This evidence concerns the gene CHKB and Alzheimer disease.