Hypermethylation in MCI-AD converters relative to MCI-MCI nonconverters was seen in 2 DMRs located in the genes SMC1B and RIBC2 (725 bp; 15 probes) (Fig. 3H), and an intergenic region near the gene FIGN (716 bp; 6 probes) (Fig. 3I). The gene discussed is RIBC2; the disease is Alzheimer disease.