Since the ABCA1, ABCA7 and ABCG1 proteins actmainly in the cholesterol metabolism, and cholesterol dysfunction in the adiposetissue could be related to a lipid imbalance in the whole body, geneticpolymorphisms in the corresponding genes could be involved in obesity-associatedmetabolic complications. This evidence concerns the gene ABCA7 and obesity due to melanocortin 4 receptor deficiency.