Silencing of the WIF1 gene due to promoterhyper-methylation has been revealed in gastrointestinal, lung and bladder cancers(Taniguchi et al., 2005;Urakami et al., 2006;Yoshino et al., 2009;Rahmani et al., 2017).It has also been observed that stimulation of WIF1 activity incancer cells allowed to treat some malignant cancers (Ng et al., 2014). This evidence concerns the gene WIF1 and urinary bladder carcinoma.