Decreased expression of WIF1 was reported in many cancers,such as gastrointestinal tract, kidney, glioblastoma, osteosarcoma, lung, pituitary,bladder, and oral cavity (Mazieres etal., 2004; Taniguchiet al., 2005; Urakami et al., 2006; Elston et al., 2007; Kawakami et al., 2009; Rubin et al., 2010; Lambiv et al., 2011; Paluszczak et al., 2015). Here, WIF1 is linked to osteosarcoma.