When re-expressed,WIF1 can down-regulate the Wnt pathway and prevent cancer cellgrowth (Gao et al., 2009;Kawakami et al., 2009;Yee et al., 2010; Hirata et al., 2011; Ramachandran et al., 2012;Jiang et al., 2016). Here, WIF1 is linked to cancer.