TRIB3 and early-onset autosomal dominant Alzheimer disease: Several mouse and cellular models have implicated increased TRIB3 in neurodegeneration and neuronal cell death [19, 63, 64], and in humans, SNP associations with information processing speed (p = 1.68e-7; rs6051520) [50] and Alzheimer’s disease (p = 6.01e-3; rs62191440) [49] correlate with the expected effects of TRIB3 33-bp repeat copy number on TRIB3 gene expression level in brain tissue.