TRIB3 and obesity due to melanocortin 4 receptor deficiency: For example, enforced overexpression of Trib3 in mouse adipose tissue has been reported to inhibit weight gain [62], and the human SNP rs6051546 alternative allele is associated with increased 33-bp repeat copy number, elevated TRIB3 mRNA level in adipose tissue, and suggestively (p = 3.47e-5) [47] with reduced obesity.