As expected, EGFR was significantly downregulated along with remarkable increase of activated caspase-3 and cleaved PARP levels in Ad-EC treated HEP-2 cells when compared with those in Ad-GFP treated HEP-2 cells, further confirmed by flow cytometric analysis data for apoptosis in vitro and tumor suppression on HEP-2 xenograft in nude mice in vivo. Here, EGFR is linked to neoplasm.