More importantly, a statistically significant increase in the secretion of IFNL1 by trophoblasts from non-affected twins was observed at 96 h after infection with ZIKVBR (p-value = 0.033), whereas in trophoblasts from CZS-affected twins no statistically significant increase of IFNL1 was observed (p-value = 0.1632) (Fig 3B, lower panel). The gene discussed is IFNL1; the disease is infection.