Interestingly, from all the analytes tested, the chemokines RANTES/CCL5 and IP10 showed a consistent (both at 48 h and 96 h post-infection) and significant increase in secretion by trophoblasts from non-affected twins after infection with ZIKVBR, but not by trophoblasts from CZS-affected twins (Fig 4C). Here, CXCL10 is linked to infection.