Noteworthy, our RNA-seq results indicate that hiPSC-derived trophoblasts express the ZIKV candidate receptor genes (HSPG2 and TAM receptor genes) and the IFN receptor genes, and at lower levels the IFN genes; however none of these genes were differentially expressed between the trophoblasts from CZS-affected and non-affected twins either before or after ZIKVBR infection. Here, IFNA1 is linked to infection.