BRD4 and cancer: Next, we compared CHD4 with other SNF2-like chromatin remodelers (Flaus et al., 2006) and the broad cancer susceptibility gene BRD4. In both databases loss of SRCAP, EP400, INO80 and BRD4 induced a general impairment of tumor cell viability, however, the lowest dependency scores were observed for CHD4 (Figure 6—figure supplement 1C and D).