CHD4 and cancer: Extraordinarily, sensitivity to CHD4 depletion seems to be specific to cancer cells as we and others observed that silencing of this chromatin remodeler had no influence on proliferation of human myoblasts, fibroblasts (Böhm et al., 2016), non-transformed mammary epithelial cells (MCF10A) (D’Alesio et al., 2016), and normal primary hematopoietic cells (Heshmati et al., 2016).