Analysis of a publicly available CRISPR-based genome-wide cancer vulnerability screen (CRISPR Avana Public 19Q2, depmap.org) for sensitivities to the depletion of NuRD subunits in 6 FP-RMS cell lines (RH28, RHJT, RH4, CW9019, JR, and RH30) confirmed the marked dependency of FP-RMS cells to CHD4 and RBBP4 (Figure 1—figure supplement 1E). This evidence concerns the gene CHD4 and cancer.