One reports disclosed that ZFAS1 could improve the migration and invasion in FLS-RA by inactivating miR-27a [29], and this conclusion prompted that ZFAS1 might be involved in the pathogenesis and development of RA, and it is of great significant to discuss the influence of ZFAS1 on RA and accurately describe the regulatory mechanism. Here, ZFAS1 is linked to rheumatoid arthritis.