Also, reintroduction of ADAMTS9 relieved the inhibitory effect of miR-2682-5p transfection on the level of ADAMTS9 at the aspects of mRNA and protein expression in RA synoviocytes, and the introduction of pcDNA-ADAMTS9 only could be enhanced the mRNA level and protein level of ADAMTS9 in RA synoviocytes. The gene discussed is ADAMTS9; the disease is rheumatoid arthritis.