Synchronously, we assayed the influence of ZFAS1 and ADAMTS9 in inflammation, the hampering role of inflammatory response caused by ZFAS1 reduction was accelerated via co-transfection with ADAMTS9 in RA synoviocytes, and the transfection of pcDNA-ADAMTS9 alone promoted the inflammatory response (Figure 4F). This evidence concerns the gene ZFAS1 and rheumatoid arthritis.