PLEKHB1 and breast cancer: As shown in Figure 3A, when knocking down on SLC39A7 gene with CRISPR–Cas9 system, CERES scores of 27 BC cell lines were less than -1 (MDAMB436, HCC1419, EFM19, MDAMB468, KPL1, SUM149PT, SUM229PE, HCC1954, SUM52PE, SKBR3, HCC1143, BT549, MDAMB453, HMC18, SUM159PT, HCC38, AU565, CAMA1, JIMT1, CAL51, MCF7, HCC1806, MDAMB231, HS578T, HCC1395, HCC1937, HCC202), which suggested significant inhibition of survival in BC cells.