The frequencies of IL-4 rs2070874 TT, TC, and CC genotypes were 486 (67.88%), 214 (29.89%), and 16 (2.23%) in ESCC cases and 780 (64.95%), 371 (30.89%), and 50 (4.16%) in controls. This evidence concerns the gene IL4 and esophageal squamous cell carcinoma.