After an adjustment, we suggested that IL-4 rs2070874 C allele was a protective factor for ESCC in five subgroups (male subgroup: CC vs. TT: P=0.028; CC vs. TT/TC: P=0.031; ≥63 years old subgroup: CC vs. TT: P=0.026; CC vs. TT/TC: P=0.029; never smoking subgroup: CC vs. TT: P=0.041; CC/TC vs. TT: P=0.013 and TC vs. TT: P=0.042; drinking subgroup: CC vs. TT: P=0.025; CC vs. TT/TC: P=0.024 and BMI < 24 kg/m2 subgroup: CC vs. TT: P=0.010; CC vs. TT/TC: P=0.012). This evidence concerns the gene IL4 and esophageal squamous cell carcinoma.