Through the analysis of various bioinformatics databases and related tools, we identified seven genes (PPARGC1A, DLAT, 6PC2, P4HA1, STC2, ANKZF1, and GPC1) that affect the prognosis of COAD, allowing a glycolysis risk scores model to be established. The gene discussed is PPARGC1A; the disease is colon adenocarcinoma.