TARDBP and Lewy body dementia: Although rare, neuropathological studies have identified a subset of centenarians without evidence of any pathological process: Neltner et al. [13] found 3 cases (4%) without evidence of significant neurofibrillary tangles, cerebral amyloid angiopathy, arteriolosclerosis, hippocampal sclerosis, TDP-43 pathology, Lewy body disease, or large infarcts whereas Ding et al. [65] identified 6 centenarians (19%) without AD, Parkinson’s disease, infarcts, white matter lesions, vascular dementia, dementia with tangles, or argyrophilic grain disease.