CXCR1 and neoplasm: Kaplan–Meier analysis confirmed that PTENLOW and CXCR1/2HIGH tumours were associated with a significantly reduced time to BCR (Figure 1D; P < 0.001; HR 2.65) and importantly with the development of metastasis (Figure 1E; P = 0.002; HR 3.51) after RT treatment.