Along these lines, PRMT5 recruitment to the FOXP1 promoter facilitates FOXP1 expression via PRMT5-dependent H3R2me2s with concomitant WDR5/SET1/MLL complex-driven H3K4me3, implicated in maintenance of stemness in breast cancer stem cells (BCSCs) [38]. The gene discussed is PRMT5; the disease is breast carcinoma.