Direct interaction of PRMT5 with the MEN1 tumor suppressor in pancreatic islet tumors reportedly increases repressive sDMAs on H4 (H4R3me2s) and suppresses Gas1, PTCH1 and c-myc expression, thereby limiting oncogenic SHH (sonic hedgehog) signaling in these tumors. The gene discussed is PRMT5; the disease is neoplasm.