PRMT5 induction and subsequent Th1 and Th17 differentiation exemplify the pathological roles played by PRMT5 in autoimmune disorders, experimental autoimmune encephalomyelitis (EAE) and acute graft-versus-host diseases (aGVHD) [98, 101, 102]. This evidence concerns the gene PRMT5 and experimental autoimmune encephalomyelitis.