Remarkably, 3p loss represents the first somatic driver event in sporadic ccRCC, which takes place during adolescence that predates the most common second somatic event by ~20 years, i.e., the genetic/epigenetic inaction of the VHL gene, giving rise to the most recent common ancestor (MRCA) within a given ccRCC patient whose ccRCC is eventually diagnosed at 60 years of age [29]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.