The most striking genomic discovery in ccRCC is the extreme chromosomal proximity of the four most prevalently mutated kidney cancer TSGs—VHL (~80%), PBRM1 (29-46%), SETD2 (8-30%), and BAP1 (6-19%)—spanning chromosome 3p21-3p25 [6, 27–28]. The gene discussed is VHL; the disease is kidney cancer.