In this sense, the objective of the present study was to identify polymorphisms in important mediators of the immune response (FOXP3, IFNG, IL6, IL8, IL10, MBL2, CRP, TGFΒ1 and TNFA) in association with ANAs, which could contribute to the development of autoimmunity in hepatitis C. This evidence concerns the gene CRP and Autoimmunity.