In the same way, TIEG-1 (TGF-β inducible early gene) is involved in this process way before the expression of the TFG-β family by binding and repressing Smad7 (responsible for the negative feedback of TGF- β / Smad) in keloids, and therefore, the subsequent overexpression of TIEG-1 and its TGF-β family release chain [21].​​​​​​. The gene discussed is TGFB1; the disease is keloid.