In view of abnormally activated ERK (p-ERK) promotes the proliferation, invasion and migration of numerous types of tumor cells (Yuan et al., 2009; Zhang et al., 2016, 2020; Zhou & Sakamoto, 2019), and NF-κB (p65) is a transcription factor closely related to EMT and its activation can significantly promote tumor invasion and angiogenesis. Here, NFKB1 is linked to neoplasm.