SPC25 and cancer: As shown in Fig. 1, high SPC25 expression was associated with patient age (P = 0.025, Fig. 1A), pathological stage (P = 0.004, Fig. 1C), histologic grade (P < 0.0001, Fig. 1D), survival status (P = 0.00029, Fig. 1E), and family history of cancer (P = 0.01, Fig. 1G).