In colorectal cancer tissues, by activating KPNA3 via recruiting SMARCA1, an essential subunit of the NURF chromatin remodelling complex, increased expression of DLEU1 was observed, and higher expression of DLEU1 in patients indicated lower survival rate and a poorer prognosis (Liu et al., 2018a). This evidence concerns the gene KPNA3 and colorectal cancer.