AKT1 and colorectal cancer: Importantly, proliferation (Fig. 5A), migration (Figs. 5B and 5D) and invasion (Figs. 5C and 5E) of HT29 and HT116 cells were significantly reduced following siRNA-mediated AKT knockdown, suggesting that targeting AKT may be effective for treatment of colorectal cancers with high SLPI expression.