For the 5-HT1A polymorphism, studies disorder have shown that following rTMS to the left DLPFC, patients with the C/C genotype had significantly greater improvement of depression as evaluated by the HDRS for depression than G/G and C/G individuals (Zanardi et al., 2007; Malaguti et al., 2011). This evidence concerns the gene HTR1A and major depressive disorder.