Mice with complete loss of function of TNF failed to keep intact the recruitment of plasmablast-producing IgA+, IgG+, and IgM+ at week 3 post-infection, leading to a significant decrease of these cells when compared with TNFf/f and BTNF-/- mice (Figures 7D–7F and supplementary Figure 2). The gene discussed is CD40LG; the disease is infection.