TNF and cancer: Some studies have revealed that chemotherapy drug resistant cancer cells such as CEM/V (vinblastin resistant leukemia), 8226/D (doxorubicin resistant myeloma), FLC-DXR (doxorubicin resistant friend erythroleukemia cell line) and B16-DXR (doxorubicin resistant melanoma) are more sensitive to cytotoxic effects of TNF-α compared to their parental cell lines (16-20).