Upregulation of 14-3-3γ in uterine leiomyoma cells and uterine leiomyoma immortal stem cells significantly elevated cell apoptosis compared to control group and decreased phosphorylated levels of some of the signaling molecules such as p-AKT1, p-AKT2 and p-Foxo1(27, 36). The gene discussed is FOXO1; the disease is Uterine leiomyoma.