In addition, parthenolide in combination with balsalazide (prodrug of 5-aminosalicylate that reduces the risk of colon cancer in patients with ulcerative colitis) significantly suppressed nuclear translocation of NF-κB in colon cancer cells and further in vivo studies in the murine model showed that this combination inhibited carcinogenesis (35). This evidence concerns the gene NFKB1 and ulcerative colitis.