In line with our findings, it has been demonstrated that parthenolide, in combination with 5-fluorouracil or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), induced sub G1 arrest in colorectal cells (16, 23), similar to ATO that increased the proportion of myeloma cells in sub G1 phase (24). This evidence concerns the gene TNFSF10 and plasma cell myeloma.