ESR1 and ovarian cancer: Bax expression was up-regulated in response to BPA exposure in granulosa cells (64) and P53 expression was induced following 24hr BPA subjection in the ovarian cancer cell line (65) Furthermore, a correlation between BPA estrogen receptor stimulation and apoptosis induction was demonstrated by assessment of apoptotic genes in different in vitro cellular cultures (35, 36, 66).