Bax expression was up-regulated in response to BPA exposure in granulosa cells (64) and P53 expression was induced following 24hr BPA subjection in the ovarian cancer cell line (65) Furthermore, a correlation between BPA estrogen receptor stimulation and apoptosis induction was demonstrated by assessment of apoptotic genes in different in vitro cellular cultures (35, 36, 66). This evidence concerns the gene TP53 and ovarian carcinoma.