In a low-grade serous ovarian cancer (LGSOC) PDX model with lack of PTEN expression, two PI3K/Akt/mTOR inhibitors (PF-04691502 and PF-05212384) added to cisplatin or paclitaxel promoted the activity of chemotherapy alone in LGSOC models, suggesting that PI3K-mTOR inhibitors contributed to the chemotherapy sensitivity to cisplatin or paclitaxel 72. The gene discussed is MTOR; the disease is ovarian serous adenocarcinoma.