Of note, Erriquezet al. 100 utilized ovarian cancer PDX models and found an overexpression of topoisomerase II alpha (TOP2A) in cells from xenograft after the treatment of pegylated liposomal doxorubicin (PLD), suggesting that TOP2A may be involved in the pathogenesis of ovarian cancer response to PLD. This evidence concerns the gene TOP2A and ovarian cancer.