Butler et al. 85 established ovarian cancer PDX models by injecting species from 568 ovarian cancer patients intraperitoneally into SCID mice and indicated that rituximab, an anti-CD20 antibody, decreased CD45-positive cells incidence in subsequent PDX lines from 86.3% (no rituximab) to 5.6% (rituximab), and reduced lymphoma rate from 11.1% to 1.88%. The gene discussed is PTPRC; the disease is ovarian cancer.