According to the data above, multivariate Cox regression model (Table 4), including the covariates of pT categories (pT1 vs. PT2/pT3), Edmondson grading (I-II vs. III-IV), tumor capsule (complete vs. incomplete), co-overexpression of both CD4 and CD8, PD-L1 expression and SOCS3 expression, exhibited that pT categories (P=0.045), CD4/CD8 expression (P=0.040), PD-L1 expression (P<0.001) and SOCS3 expression (P<0.001) were independent predictive factors for OS. The gene discussed is CD4; the disease is neoplasm.