Additionally, L1CAM has been found to be a potential biomarker in several types of human cancers 21,23, including esophageal squamous cell cancer (ESCC) 22, gastrointestinal stromal tumors (GIST) 24, uterine and ovarian cancers 25 and other less common types of cancer. This evidence concerns the gene L1CAM and esophageal squamous cell carcinoma.