The E7 oncoprotein binds preferentially to the tumor suppressor pRb and disrupts the pRb/E2F transcriptional repressor complex to initiate oncogenic transformation, leading to dysregulation of epithelial cell growth, which eventually leads to CIN progression, ultimately causing cervical cancer 13, 14. This evidence concerns the gene RB1 and cervical squamous intraepithelial neoplasia.