ACE2 and neoplasm: In the two types of NSCLCs, expression of ACE2 was significantly upregulated in tumors compared to normal tissues, with a median level of 1.44 in tumor and 0.89 in normal tissue in LUAD (482 tumors versus 347 normal, p<0.05), and a median level of 1.13 in tumor and 0.87 in normal tissue in LUSC (486 tumors versus 338 normal, p<0.05) (Figure 1B).