The present study found that the DNA methylation level of ACTL10 was a strong independent risk factor for EFS (HR =4.6053; 95% CI, 2.1979-9.6495; P=5e-05; Cox regression analysis; Table 2) and OS (HR =3.1101; 95% CI, 1.646-5.8764; P=0.0005; Cox regression analysis; Table 2) in patients with CN-AML. This evidence concerns the gene ACTL10 and acute myeloid leukemia.