ACTL10 and acute myeloid leukemia: EFS and OS was subsequently compared between the ACTL10 DNA methylation high-group and the ACTL10 DNA methylation low-group in 85 patients with CN-AML (TCGA dataset); patients with CN-AML and low levels of ACTL10 DNA methylation had a longer EFS (P<0.0001; log-rank test; Fig. 2A) and OS (P=0.004; log-rank test; Fig. 2A).