Age was also found to be a high risk factor for ACTL10 RNA expression (EFS, HR =2.5725; 95% CI, 1.1378-5.8163; P=0.0232; OS, HR = 3.2294; 95% CI, 1.5521-6.7192; P=0.0017; Cox regression analysis; Table 2) and ACTL10 DNA methylation (EFS, HR=3.0966; 95% CI, 1.3541-7.0816; P=0.0074; OS, HR=4.0511; 95% CI, 1.933-8.4901; P=0.0002; Cox regression analysis; Table 2) in patients with CN-AML. This evidence concerns the gene ACTL10 and acute myeloid leukemia.