CXCR4 and esophageal squamous cell carcinoma: Importantly, individuals with the CXCR4 rs6430612 CT genotype showed 43% decreased risk to develop ESCC compared with those with the CXCR4 CC genotype in Shandong set (95% CI = 0.42-0.78, P = 4.0×10-4) (Table 2).