In line with this, carriers of TERT rs13172201 CT or TT genotype showed 1.33-fold elevated risk to develop ESCC compared with carriers of the CC genotype (95% CI = 1.08-1.64, P = 0.007; OR = 1.52, 95% CI = 1.14-2.02, P = 0.004) in Shandong set (Table 3). The gene discussed is TERT; the disease is esophageal squamous cell carcinoma.