After performing univariate regression, LASSO regression and multivariable Cox regression analyses, six glucose metabolism related DEGs (FBP1, GYG2, KAT2A, LGALS1, PFKP, and RGN) were selected to develop a risk signature for the prediction of ccRCC clinical prognosis. This evidence concerns the gene GYG2 and nonpapillary renal cell carcinoma.