RYR2 and neoplasm: The top 10 mutated genes in all the LUAD samples were TP53, KRAS, XIRP2, ZFHX4, USH2A, LRP1B, CSMD3, RYR2, MUC16, and TTN (Figure 2B), and these are listed in Table 2A. Similarly, for all the LUSC samples and samples with different tumor stages, the most frequent variant was missense mutation, followed by nonsense mutation.