Before, it has been verified low expression of gastric cancer-associated fibroblasts-derived SPARC could lead to cancer stem cell transformation and 5-FU resistance 41; FN1 was significantly up-regulated in GC tissues and down-regulation of FN1 could inhibit the proliferation, migration and invasion of GC cells 42; Patients with low expression of THBS2 had a positive prognosis 43. This evidence concerns the gene SPARC and cancer.