CDK4 and gastric cancer: For example, miR-29a-3p showed a significant down-regulated expression in GC tumor tissues and high expression of miR-29a-3p inhibited cell proliferation and metastasis by targeting CDK2, CDK4, and CDK6 44; Tao et al. indicated that miR-27b-3p exerts tumor-suppressive effects in GC via the inhibition of oncogene ROR1 expression 45.