Taken the results of expression analysis and survival analysis into consideration, 8 up-regulated hub genes (FN1, COL3A1, FBN1, BGN, COL5A2, THBS2, COL5A1 and SPARC) were discovered not only significantly up-regulated in gastric cancer groups but also predicted poor prognosis in patients with gastric cancer (Figure 4A and Figure 4C-J). This evidence concerns the gene COL5A2 and gastric cancer.