For instance, lncRNA CASC11 was overexpressed in hepatocellular carcinoma and promotes cell proliferation by suppressing miRNA-188-5p 31; Bai et al. found that lncRNA LOXL1-AS1/miR-let-7a-5p/EGFR axis obviously changed proliferation, migration and apoptosis of drug-resistant DU-145 Cells, providing a promising treatment approach for drug-resistant prostate cancer patients 32; Similar studies have been reported in gastric cancer. The gene discussed is EGFR; the disease is Familial prostate cancer.