Downregulated genes in the perilesional cortex as compared to the corresponding cortical area of the sham-operated aged rats, included genes like dopamine receptor D1A (Drd1a) involved in feeding behavior (de Souza et al., 2020) and depression (Amiri et al., 2016), glutamate decarboxylase (Gad1) and solute carrier family 5 member D (Slc5d3) involved in neuronal development (Lu et al., 2014), schizophrenia (Tao et al., 2018) and autophagy (Wei et al., 2016) as well as ubiquitin specific peptidase 11 (Usp11)(Table 1). This evidence concerns the gene USP11 and major depressive disorder.