Behaviorally, the aged rats could also have benefitted from the downregulation of genes involved in schizophrenia like solute carrier family 5member D (Slc5d3) (Tao et al., 2018), or transcripts encoding adenosin A2a receptor (Adora2a) and ermin (Ermn) have been associated with neurodegeneration (Stockwell et al., 2017), multiple sclerosis and epileptic seizures (Wang et al., 2011; Salek Esfahani et al., 2019). This evidence concerns the gene ADORA2A and schizophrenia.