However, due to failure of NSAIDs and selective COX-2 inhibitors against AD, alternate views are being considered which think of these drugs to perhaps have a preventive role with respect to AD and inflammation as merely a secondary phenomenon to clear off debris generated from more central underlying processes of AD (Wyss-Coray and Mucke, 2002; Hoozemans et al., 2006). The gene discussed is PTGS2; the disease is Alzheimer disease.