This, along with other studies showing associations between COX-2 induction and neurodegeneration (Miettinen et al., 1997) as well as brain parenchymal amyloid plaque formation (Stewart et al., 1997), sparked interest, and subsequent research on potential effects of the COX enzymes and their various pathways in AD progression as NSAIDs are known inhibitors of COX. This evidence concerns the gene PTGS2 and Alzheimer disease.