Interconnected signaling and working of COX-2 and mTOR has been the subject of many studies in the case of various types of cancer (Chuang et al., 2019(H. Lipskar et al., 2009; Rouzer and Marnett, 2009; Li H. et al., 2016), but no such studies have yet been conducted for AD. The gene discussed is PTGS2; the disease is Alzheimer disease.