When comparing early stage urine samples to those from patients with higher staged disease (progressive ccRCC group), five proteins were elevated EPS8L2, CHMP2A, PDCDPI6, CNDP2, and CEACAM1, with authors finding the combined urinary abundance of EPS8L2 and another protein, CCT6A, to have prognostic value in ccRCC. The gene discussed is CNDP2; the disease is nonpapillary renal cell carcinoma.