Quantitative assessment via LFQ or 2-DE profiling revealed the increasing expression of APOA, FN, HP, and MGAT4A in controls, good prognosis ccRCC samples, and poor prognosis samples, with a concordant decrease in abundance of the proteins KNG1, UMOD, APOD, UBC, CD59, and HSPG2. The gene discussed is FN1; the disease is nonpapillary renal cell carcinoma.