In another study, comparison of nine cases of ccRCC (paired tumor tissue and NAT) revealed the differential expression of 34 proteins, including the protein NDRG1, which was found to be elevated in ccRCC tissues, with subsequent validation experiments via IHC revealing the protein’s nuclear localization (versus membrane localization) was associated with a favorable prognosis, and functional assays revealing a potential tumor suppressor role of NDRG1 in ccRCC [29]. This evidence concerns the gene BRD2 and nonpapillary renal cell carcinoma.