Evaluating a panel of antibodies comprised of MKI67, TP53, VEGFR1 (FLT1), VEGFD, SNAIL (SNAI1), and SLUG (SNAI2) paired with a technology called Automated Quantitative Analysis (AQUA) that allows for an unbiased assessment of protein expression, the authors showed all the proteins, except for VEGFD, were significantly elevated in metastatic disease relative to VTT and primary lesions. Here, SNAI2 is linked to metastatic neoplasm.