Pathway analysis of the differentially expressed proteins revealed higher expression proteins involved in glycolysis (PGK1, ALDOA-C, ENO1) xenobiotic metabolism (ALDH4A1, ALDH1A1, ALDH9A1), and down-regulation of proteins associated with apoptosis (AIFM1) were associated with higher tumor grade and are representative of the cellular mechanisms involved in ccRCC progression. Here, ENO1 is linked to nonpapillary renal cell carcinoma.