EPS8L2 and nonpapillary renal cell carcinoma: When comparing early stage urine samples to those from patients with higher staged disease (progressive ccRCC group), five proteins were elevated EPS8L2, CHMP2A, PDCDPI6, CNDP2, and CEACAM1, with authors finding the combined urinary abundance of EPS8L2 and another protein, CCT6A, to have prognostic value in ccRCC.