Interestingly, when evaluating differential expression of phospho-substrates in ccRCC and pRCC tumors, EGFR-Y1197, ERK2-Y187, ERK1-Y204, and TENC1-Y483 were elevated in ccRCC, while DDR1-Y792/6 and PP4B-Y849 were elevated in pRCC. Here, MAPK3 is linked to nonpapillary renal cell carcinoma.