In this study, we analyzed the FOXD3-AS1 in cisplatin-resistant NSCLC cell lines (A549/DDP and H1229/DDP cells) and explored the underlying mechanisms of FOXD3-AS1 in regulating cisplatin resistance in A549/DDP and H1229/DDP cells. The gene discussed is FOXD3; the disease is non-small cell lung carcinoma.