SMO and meningioma: In addition, recent genomic analyses of meningioma using next-generation sequencing have identified mutations in the TNF receptor-associated factor 7 (TRAF7), the Kruppel-like factor 4 (KLF4), the v-Akt murine thymoma viral oncogene homolog 1 (AKT1), and the smoothened (SMO) gene [25, 26].