SMO and meningioma: Several other studies based on whole-genome sequencing have reported the presence of somatic mutations in the G-protein-coupled receptor, Smoothened (SMO), and in the mTOR pathway associated serine-threonine protein kinase, and V-AKT murine thymoma viral oncogene homologue 1 (AKT1) in non-NF2 meningiomas [25, 26].