Genipin might down-regulate matrix metalloproteinases genes and protein expressions; decrease the expression of nuclear factor kappa-light-chain-enhancer of activated B cells, phosphorylated protein kinase B, urokinase-type plasminogen activator, phosphorylated mitogen-activated protein kinase, and activator protein 1; and up-regulate tissue inhibitor metalloproteinases genes as well as the protein expression in HCC [36]. The gene discussed is PLAU; the disease is hepatocellular carcinoma.