A third example is provided by the study of rat mutated in the Pde3a gene, which recapitulates the phenotype of HTNB (Hypertension with brachydactyly) human patients: the functional data suggest that soluble guanyly cyclase activation could be suitable for the treatment of HTNB patients [46] (See Table 1B, Blood pressure section). Here, PDE3A is linked to brachydactyly-arterial hypertension syndrome.