Despite the inclusion of IgA aPL isotypes in the recent SLE classification criteria,9 there is yet no strong evidence relating these antibodies to thromboticand/or pregnancy morbidity risk.7,21 We investigated aPL associations with APS-related clinical events using thecommon conventional and the adjusted cut-offs to the 95th percentiles of nationalcontrols. This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.