A positive association with APS-related eventswas demonstrated in several studies for both IgA aCL2,3,10 as well as IgA anti-β2GPI.2,4,11, –13 However, other investigatorscould not confirm these associations.3,10,14,15 Interpretation of data provided by previous studies on aPL in general and IgAaPL in particular and the relationship to APS features is rather complex. This evidence concerns the gene CD79A and autoimmune polyendocrinopathy.